There’s been some talk on HipChat regarding various vague incompatibilities between the stack and various Mac OS package managers. It seems like we should gather some of those experiences and try to determine exactly what we are compatible or incompatible with, and possibly figure out why.
I don’t have any direct experience with any of the Mac package managers, but at one point I think I came to the conclusion that Homebrew was the only one for which real compatibility with EUPS was possible, since (I think) it puts the files it installs into per-package prefix directories, though I think it also puts symlinks to all of them into a single prefix directory. It’s the latter kind of thing that causes problems (because you put the everything-prefix into your various paths to get one package, and then something else in that directory overrides something EUPS provides).